First I'm assuming the last picture is the bow braced. It looks like the back of the bow at the handle is not level. Remember the back needs to level, even if both limbs bend there, they should bend evenly. DON"T tiller by trying to keep the string level. It will cause the tiller to go ALL WONKY (I did that once).
I have no experience with knot holes. Maybe Blackhawk with chime in. So take this advice with a grain of salt. The knot has been removed leaving just the hole, correct? From what I've seen on here, it looks like most folks just tiller through the hole. In theory, if your limb is 1 1/2 wide and 2 inches wide at the hole and the hole is 1/2 diameter, then you have 1 1/2 of "wood" at the hole the same as you do for the rest of the limbs. AGAIN, this theory is only speculation and may be complete BS.
What I would do is: measure and mark 2" intervals from the center of the bow out the knot on that limb them do the same out to the same distance on the other limbs. With the bow braced, measure from belly to string at each 2" mark. This will give you an idea of how to even up the bend and brace. Remember when you remove wood from the stiff limb it will relieve tension on the weaker limb. So, measure both of them again after removing wood and exercising the bow.