While all the tips are true... I've found my self in the corner with only flawed horns and great anticipation to shoot the bow.
So, what i've done is made these sort of viktorian style nocks that the string loop groove goes all around the nock, instead of mary rose style side nock. Sidenocks great bigger splitting pressure, while those sort of back nocks give all around pressure. Also leaving the horn a bit thicker, helps.
Material difference matters, buffalo horn is tolerant, cow horn not so. My success was with buffalo horns that had some checks, they are still hanging on that bow. The bow is 110 pound tonkin-ip longbow, shot with fastflight and 300 grain arrows as the first ever shot. Actually that bow haven't ever been shot with heavier than 400 grain arrows.